I've reviewed a few punk genre films (Cheech & Chong's Up In Smoke (1978), The Driller Killer (1979), Repo Man (1984) ) and here is another one.
What this is, really, is an Animal House (check out the poster) inspired New Line musical comedy (also see Get Crazy (1983)), with actual if light genre content and light surrealist gags (like an out of nowhere game show presentation,) but with plenty of cult appeal: Mary Woronov, Paul Bartel, Dick Miller, Joe Dante, Roger Corman & Rob Bottin are a few of the names associated with it.
The genre content consists of vague, rock and roll experiments which result in exploding lab mice (also see Alien Contamination (1980)), but additionally in enlarged, sentient, speaking rodents (smart R.O.S. if you will.)
One could also make a case that the apocalyptic end mimics Lindsay Anderson's If.... (1968) with the destruction of a school once students are pushed just a bit too far.
The tone is all over the place, as the exploitative (with no nudity, but with lots of drug humor) story consists basically of a comedic race to get laid and/or to get Ramones tickets, and yet, unlike Massacre at Central High (where serial murders happen in a law enforcement vacuum,) there are immediate consequences to the hi-jinks, with confrontations with hall monitors, calls to the principal's office and ultimately even the cops called in.
Also, unlike If..... the final scene is no mere surreal dream scene, but it is something that actually happens, the school explodes aided with the contents of the chemistry lab.
Other than the strange climax, which does seem badly conceptualized (I believe it's Danny Peary's biggest complaint,) the movie is a comedic vehicle for Ramones songs, in addition to a few other Rock n' Roll tunes (even Alley Cat,) New Line managed to get the rights to.
If you like The Ramones (who here look like Peter Bagge cartoons come to life) this is a must see.